Cancer Drug Research will now be fuelled by DNA repair discovery

SHARE:

Tomas Lindahl, Aziz Sancar and Modrich claimed the 2015 Nobel Prize in Chemistry for “mechanistic studies of DNA repair,” this Wednesday.

Tomas Lindahl, Aziz Sancar and Modrich claimed the 2015 Nobel Prize in Chemistry for “mechanistic studies of DNA repair,” this Wednesday. Their work exhibit how the DNA is repaired by the cells for preventing damage from passing down to genetic information. With this discovery, cancer researchers all around the world started working on understanding this to be used in cancer drugs. DNA gets damaged when the cell division takes place. The work by these three scientists explains how cells repair this damaged DNA (deoxyribonucleic acid).
Cancer Drug Research will now be fuelled by DNA repair discovery

People get cancer when these DNA repair mechanisms fail. Paul Modrich from Duke University and Howard Hughes Medical Institute discovered that people with mismatch repair defects are more at the risk of contracting cancer. Dr. Bert Vogelstein  from Johns Hopkins Kimmel Cancer Centre and Richard Kolodner of Hardvard Medical School (now at University of California, San Diego) did some subsequent work on this study and showed that such mismatch defects are the major cause behind most common of inherited cancer called the ‘colorectal cancer’. Also this is the major cancer causing factor in 15 percent of the cancer patients suffering from colorectal cancer.

These defects can now be a major help in predicting if a patient would benefit from the immunotherapies. This discovery holds the key to developing new drugs that work on our immune system to ward off cancer. Earlier this year one small study was published in new England journal of Medicine stating that 92 percent of the colon and rectal cancer patients having mismatch defects were benefitted from ‘Keytruda’ which is an immuno therapy developed by Merck & Co’s. This response was compared with the response of 16 percent of the same cancer patients not having this defect. There is a hope these findings might also be helpful to the patients with other types of cancer who have the same mismatch defects. In a telephonic interview Vogelstein said, “Mismatch repair defects are found not only in hereditary colorectal cancers. They are found in about 2 percent of cancer patients overall.” Pertaining to the fact that our immune system is capable of recognizing the foreign bodies, researchers from Hopkins believe that immune – booster drugs (BMY .N’s Opdivo, Keytruda etc.) will be a better option in the case of mutation loaded tumours. If this strategy could be extended to other cancers, Volgelstein said, “It could provide a very useful therapy for as many as one in 50 patients with cancer worldwide.”

Image Source: NDTV.com

COMMENTS

Name

Animal Apple Automotives Business Cancer CES Earth Economy Egypt Entertainment Environment ESPN Europe Finance Food Gaming Greece Health History IFA2015 India iOS Iran Market Mars Mice NASA National Nature NZ Obama Oil Pollution POTUS Research Science Smartphone Space Technology Temperature WhiteHouse World YouTube
false
ltr
item
Washington Account: Cancer Drug Research will now be fuelled by DNA repair discovery
Cancer Drug Research will now be fuelled by DNA repair discovery
Tomas Lindahl, Aziz Sancar and Modrich claimed the 2015 Nobel Prize in Chemistry for “mechanistic studies of DNA repair,” this Wednesday.
http://2.bp.blogspot.com/-lGfKPFRl5Cc/Vha3PVcOmOI/AAAAAAAAAW0/Th7pONg121I/s640/tomas-lindahl.jpg
http://2.bp.blogspot.com/-lGfKPFRl5Cc/Vha3PVcOmOI/AAAAAAAAAW0/Th7pONg121I/s72-c/tomas-lindahl.jpg
Washington Account
http://www.washingtonaccount.com/2015/10/cancer-drug-research-will-now-be_8.html
http://www.washingtonaccount.com/
http://www.washingtonaccount.com/
http://www.washingtonaccount.com/2015/10/cancer-drug-research-will-now-be_8.html
true
9223304746932238000
UTF-8
Not found any articles VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES ARTICLES View All RECOMMENDED FOR YOU SECTION ARCHIVE SEARCH ALL ARTICLES Not found any news story match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS CONTENT IS PREMIUM Please share to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy